The Silvio O. Conte center dopamine dysfunction in Schizophrenia

nyspifacadefaded The Silvio O. Conte Center
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Center Cores

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Administrative Core

The Functions of the Core: 1) Monitoring progress in each project so that milestones are achieved as planned and information is shared among the different components of the Center; this includes oversight of the integration between the different Projects and the interaction with the Cores supporting them 2) interaction with the External Advisory Board 3) performance of standard administrative tasks such as budget management; interactions with other participating insti-tutions, assurance of adequate resources; interacting with regulatory agencies; 4) interfacing with training programs in schizophrenia research; and 5) disseminating information and conducting outreach to the general public, including, but not restricted to, the creation and maintenance of this Center website.

The Structure of the Core: The leadership team of the Administrative Core consists of the following key personnel: the PI, Anissa Abi-Dargham, MD, the two co-PIs of the Center: Eric Kandel, MD, and Jonathan Javitch, MD, PhD and co-PI of the Core, Jeffrey Lieberman, MD, thus forming a team of multidisciplinary scientists who can oversee all Projects and all Cores while facilitating access to Resources and allowing efficient decision making and communication. Furthermore, as co-investigator on the Center, Holly Moore, PhD, will assist specifically with Training, and, as significant collaborator, Laurie Flynn, BA, will assist with dissemination and outreach efforts.

Clinical Core

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The Functions of the Core: 1) Recruitment of drug-naive patients with schizophrenia and related disorders and healthy control subjects through the Division of Translational Imaging at the New York State Psychiatric Institute (NYSPI). 2) Diagnosis /Assessment of patients participating in the Center's research protocols to ensure uniformity of assessments and measures across the projects and over time. 3) Coordination of research and inpatient treatment as well as follow-up care in the Schizophrenia Research Clinic (SRC). 4) Careful review of ethical and safety aspects of all studies to ensure protection and safety of all research subjects.

The structure of the Clinical Core: The leadership team of the Clinical Core consists of the following key personnel: the PI, Lawrence Kegeles, MD, PhD and three co-investigators: Jill Harkavy-Friedman, PhD, Roberto Gil, MD, and Tom Cooper MA.

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Brain Imaging and Statistics Core

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The Functions of the Core: 1) Oversee and perform all data acquisition and analysis for all imaging experiments, including human and rodent PET scans, fMRI and structural MRIs. 2) Radioligand research and database management. 3) Foster synthesis and interaction between imaging projects in the form of a common set of analytic methods. 4) Oversee data analysis and comparisons between projects.

The structure of the Core: The leadership team of the Brain Imaging Core consists of the following key personnel: the PI, Mark Slifstein, PhD and co-investigators Balu Easwaramoorthy, PhD and Dileep Kumar JS, PhD, and Jared Van Snellenberg, PhD and consultant Tor Wager PhD.

Animal Models Core

The Functions of the Core: 1) Providing facilities and expertise for the neurochemistry, electrochemistry and extracellular single-unit recording experiments, 2) Fostering collaboration and interaction between animal projects carried out at NYSPI and Rochester University, 3) Overseeing translational analysis and comparison between rodent and monkey projects, 4) Coordinating the performance of combined neurochemistry and receptor binding studies in the mouse with the Brain Imaging Core.

The structure of the Core: The leadership team of the Animal Models Core consists of the following key personnel: the PI, Holly Moore, PhD and the co-investigator David Sulzer PhD.

Techniques: In vivo microdialysis coupled with high-performance liquid chromatography, in vivo amperometry, neurohistology (including immunohistology), microscopy and quantitative neuroanatomy, receptor binding assays (in collaboration with the Brain Imaging Core), and cognitive and behavioral testing.

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